Vitamin D supply in children with chronic viral hepatitis B

Purpose — to investigate the vitamin D supply in children with chronic viral hepatitis B (HBV) depending on activity of and stage liver fibrosis. Materials methods. Fifty HBV were examined. All underwent a comprehensive examination according recommendation elastography shear wave parenchyma determine Serum 25(OH)D concentration was determined verify diagnosis deficiency. The peculiarities HBV, gender, age, fibrosis, evaluated. study included who did not receive calcium for 6 months. Results. Children senior scholl age predomnanted among surveyed. more often registered boys 66.0% (n=33), while girls only 34.0% (n=17) (χ2=10.24; p=0.01). Among examined significantly (n=33) we observed HBeAg-positive hepatitis, 18.0% (n=9) diagnosed infection, HBeAg-negative infection 14.0% (n=7) children. In vast majority (70.0%) patients serum reduced (χ2=16.0; average 59.85 [13.4–181] nmol/l zone insufficiency. optimal found 30.0% (n=15) children, insufficiency 42.0% (n=21), deficiency 14 (28.0%). Gender, biochemical do affect level (p>0.05). analysis fibrosis reveal differences median between groups but all number low concentrations prevailed. Conclusions. is characterized mainly by course, predominance parenteral route infection. most reduced. There no statistically significant difference levels hepatitis. cirrhosis deficient D. research carried out accordance principles Helsinki declaration. protocol approved Local ethics committee participating institution. informed consent patient obtained conducting studies. No conflict interest declared authors. Key words: B, D, activity,